Tumor necrosis factor α, interleukin-6, interluikin-8, and interferon α in children with viral hepatitis
C Wen, D Yongsui, F Feng, L Ge - Journal of Tongji Medical University, 1998 - Springer
C Wen, D Yongsui, F Feng, L Ge
Journal of Tongji Medical University, 1998•SpringerTo investigate the cellular immunological changes in children with viral hepatitis, interleukin
6 (IL-6), interleukin 8 (IL-8), interferon α (IFN α), and tumor necrosis factor α (TNF α) in
supernatant of cultured peripheral blood mononuclear cells (PBMCs) of 49 children with
hepatitis At B or C were measured. The levels of IL-6, IL-8, TNF α in PBMCs of the 3 viral
hepatitis groups were increased and the level of IFN α decreased as compared with those of
normal control group. But there were no significant differences among the 3 viral hepatitis …
6 (IL-6), interleukin 8 (IL-8), interferon α (IFN α), and tumor necrosis factor α (TNF α) in
supernatant of cultured peripheral blood mononuclear cells (PBMCs) of 49 children with
hepatitis At B or C were measured. The levels of IL-6, IL-8, TNF α in PBMCs of the 3 viral
hepatitis groups were increased and the level of IFN α decreased as compared with those of
normal control group. But there were no significant differences among the 3 viral hepatitis …
Summary
To investigate the cellular immunological changes in children with viral hepatitis, interleukin 6 (IL-6), interleukin 8 (IL-8), interferon α (IFNα), and tumor necrosis factor α (TNFα) in supernatant of cultured peripheral blood mononuclear cells (PBMCs) of 49 children with hepatitis At B or C were measured. The levels of IL-6, IL-8, TNFα in PBMCs of the 3 viral hepatitis groups were increased and the level of IFNα decreased as compared with those of normal control group. But there were no significant differences among the 3 viral hepatitis groups. It was concluded that cellular immunological disorders were related to the onset and the induced damage of the viral hepatitis in children.
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