[HTML][HTML] Interleukin-6 and the soluble interleukin-6 receptor induce stem cell factor and Flt-3L expression in vivo and in vitro
M Peters, F Solem, J Goldschmidt, P Schirmacher… - Experimental …, 2001 - Elsevier
OBJECTIVE: We recently established transgenic animals expressing either interleukin-6 (IL-
6) or the soluble IL-6 receptor (sIL-6R) alone, or both components, IL-6 and the sIL-6R, in
the liver. This animal model demonstrated that the expression of IL-6 in combination with its
sIL-6R led to extramedullary expansion of hematopoietic progenitor cells in the spleen and
liver. MATERIALS AND METHODS: We studied other relevant hematopoietic cytokines
involved in the IL-6/sIL-6R–induced stimulation of hematopoiesis. RESULTS: Using …
6) or the soluble IL-6 receptor (sIL-6R) alone, or both components, IL-6 and the sIL-6R, in
the liver. This animal model demonstrated that the expression of IL-6 in combination with its
sIL-6R led to extramedullary expansion of hematopoietic progenitor cells in the spleen and
liver. MATERIALS AND METHODS: We studied other relevant hematopoietic cytokines
involved in the IL-6/sIL-6R–induced stimulation of hematopoiesis. RESULTS: Using …
