Murine model of atopic dermatitis associated with food hypersensitivity
XM Li, G Kleiner, CK Huang, SY Lee… - Journal of allergy and …, 2001 - Elsevier
Background: Atopic dermatitis (AD) is an eczematous skin eruption that generally begins in
early infancy and affects up to 12% of the population. The cause of this disorder is not fully
understood, although it is frequently the first sign of atopic disease and is characterized by
an elevated serum IgE level, eosinophilia, and histologic tissue changes characterized early
by spongiosis and a CD4+ TH2 cellular infiltrate. Hypersensitivity to foods has been
implicated as one causative factor in up to 40% of children with moderate-to-severe AD …
early infancy and affects up to 12% of the population. The cause of this disorder is not fully
understood, although it is frequently the first sign of atopic disease and is characterized by
an elevated serum IgE level, eosinophilia, and histologic tissue changes characterized early
by spongiosis and a CD4+ TH2 cellular infiltrate. Hypersensitivity to foods has been
implicated as one causative factor in up to 40% of children with moderate-to-severe AD …
