[HTML][HTML] Demonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formation
Y Hirako, J Usukura, Y Nishizawa, K Owaribe - Journal of Biological …, 1996 - ASBMB
The 180-kDa bullous pemphigoid antigen (BP180) is a hemidesmosomal transmembrane
glycoprotein comprising interrupted collagen domains in its extracellular part. BP180 is also
termed type XVII collagen. But the question of whether it actually takes a collagen-like triple
helical conformation in vivo has remained unanswered. Using a monoclonal antibody, we
found that a subpopulation of BP180 localizes at the lateral surfaces of corneal basal cells
and cultured cells, in addition to the basal surface. This subpopulation of BP180 could be …
glycoprotein comprising interrupted collagen domains in its extracellular part. BP180 is also
termed type XVII collagen. But the question of whether it actually takes a collagen-like triple
helical conformation in vivo has remained unanswered. Using a monoclonal antibody, we
found that a subpopulation of BP180 localizes at the lateral surfaces of corneal basal cells
and cultured cells, in addition to the basal surface. This subpopulation of BP180 could be …
