Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production
M Korenaga, T Wang, Y Li, LA Showalter… - Journal of Biological …, 2005 - ASBMB
Hepatitis C infection causes a state of chronic oxidative stress, which may contribute to
fibrosis and carcinogenesis in the liver. Previous studies have shown that expression of the
HCV core protein in hepatoma cells depolarized mitochondria and increased reactive
oxygen species (ROS) production, but the mechanisms of these effects are unknown. In this
study we examined the properties of liver mitochondria from transgenic mice expressing
HCV core protein, and from normal liver mitochondria incubated with recombinant core …
fibrosis and carcinogenesis in the liver. Previous studies have shown that expression of the
HCV core protein in hepatoma cells depolarized mitochondria and increased reactive
oxygen species (ROS) production, but the mechanisms of these effects are unknown. In this
study we examined the properties of liver mitochondria from transgenic mice expressing
HCV core protein, and from normal liver mitochondria incubated with recombinant core …
