Effects of N-acetylcysteine on microalbuminuria and organ failure in acute severe sepsis: results of a pilot study
HD Spapen, MW Diltoer, DN Nguyen, I Hendrickx… - Chest, 2005 - Elsevier
Study objective The level of microalbuminuria is thought to reflect the severity of
inflammation-induced systemic vascular permeability and may have prognostic value with
regard to organ dysfunction and survival. N-acetylcysteine (NAC) has been shown to
decrease capillary leakage in experimental sepsis. The present study investigated the effect
of early treatment with NAC on microalbuminuria and organ dysfunction in severe clinical
sepsis Design Prospective, randomized, placebo-controlled study Setting A 24-bed …
inflammation-induced systemic vascular permeability and may have prognostic value with
regard to organ dysfunction and survival. N-acetylcysteine (NAC) has been shown to
decrease capillary leakage in experimental sepsis. The present study investigated the effect
of early treatment with NAC on microalbuminuria and organ dysfunction in severe clinical
sepsis Design Prospective, randomized, placebo-controlled study Setting A 24-bed …
