[HTML][HTML] Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin β receptor reveals a novel mechanism of apoptosis
J Kuai, E Nickbarg, J Wooters, Y Qiu, J Wang… - Journal of Biological …, 2003 - ASBMB
Lymphotoxin-β receptor (LTβR) is a member of tumor necrosis factor receptor family and
plays essential roles in the embryonic development and organization of secondary lymphoid
tissues. It binds two types of tumor necrosis factor family cytokines, heterotrimer LTα1β2 and
homotrimer LIGHT, and activates multiple signaling pathways including transcriptional factor
NFκB, c-Jun N-terminal kinase, and cell death. However, the molecular mechanism of the
activation of these signaling pathways by LTβR is not clear. Because there is no enzymatic …
plays essential roles in the embryonic development and organization of secondary lymphoid
tissues. It binds two types of tumor necrosis factor family cytokines, heterotrimer LTα1β2 and
homotrimer LIGHT, and activates multiple signaling pathways including transcriptional factor
NFκB, c-Jun N-terminal kinase, and cell death. However, the molecular mechanism of the
activation of these signaling pathways by LTβR is not clear. Because there is no enzymatic …
