Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C
J Li, RM Baxter, L Weiner, PF Goetinck, E Calautti… - Differentiation, 2007 - Elsevier
The transcription factor Foxn1 (the product of the nude locus) promotes the terminal
differentiation of epithelial cells in the epidermis and hair follicles. Activated early in terminal
differentiation, Foxn1 can modulate the timing or order of trait acquisition, as it induces early
features of epidermal differentiation while suppressing late features. Here, we identify
protein kinase C (PKC) as a key target of Foxn1 in keratinocyte differentiation control. Foxn1
has broad negative effects on the PKC family, as the loss of Foxn1 function leads to higher …
differentiation of epithelial cells in the epidermis and hair follicles. Activated early in terminal
differentiation, Foxn1 can modulate the timing or order of trait acquisition, as it induces early
features of epidermal differentiation while suppressing late features. Here, we identify
protein kinase C (PKC) as a key target of Foxn1 in keratinocyte differentiation control. Foxn1
has broad negative effects on the PKC family, as the loss of Foxn1 function leads to higher …
