NZB/NZW mice as a model of systemic lupus erythematosus
EL Dubois, RE Horowitz, HB Demopoulos, R Teplitz - Jama, 1966 - jamanetwork.com
In 1961, Helyer and Howie 1 described a strain of hybrid New Zealand mice (NZB/BL-
NZY/BL) in which a positive response to lupus erythematosus (LE) cell test spontaneously
developed. They subsequently reported that these animals also had acquired hemolytic
anemia and renal disease which simulated human lupus nephropathy. 2, 3 This was the first
description of a disease resembling human systemic lupus erythematosus (SLE) in the
animal. The purpose of this paper is to confirm their findings and to describe the results of …
NZY/BL) in which a positive response to lupus erythematosus (LE) cell test spontaneously
developed. They subsequently reported that these animals also had acquired hemolytic
anemia and renal disease which simulated human lupus nephropathy. 2, 3 This was the first
description of a disease resembling human systemic lupus erythematosus (SLE) in the
animal. The purpose of this paper is to confirm their findings and to describe the results of …
