Reduction of food intake and body weight by chronic intraventricular insulin infusion
DJ Brief, JD Davis - Brain research bulletin, 1984 - Elsevier
This study examined the effect of chronic infusions of insulin in one of three doses (5, 7.5 or
10 mU/day) into the third ventricle, on food and water intake and body weight in the rat.
Solutions were infused via osmotic minipumps at a rate of 1 μ1/hour for seven days. The two
highest doses of insulin produced a dose-related suppression of food intake and weight
loss, which was greater than the effect produced by 5 mU/day or a control infusion of
Ringers solution. The effect of 5 mU/day on food and water intake and body weight was …
10 mU/day) into the third ventricle, on food and water intake and body weight in the rat.
Solutions were infused via osmotic minipumps at a rate of 1 μ1/hour for seven days. The two
highest doses of insulin produced a dose-related suppression of food intake and weight
loss, which was greater than the effect produced by 5 mU/day or a control infusion of
Ringers solution. The effect of 5 mU/day on food and water intake and body weight was …
