Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L-thiocitrulline and S-ethyl-L …
ES Furfine, MF Harmon, JE Paith, RG Knowles… - Journal of Biological …, 1994 - ASBMB
Potent and selective inhibition of neuronal nitric oxide synthase (nNOS) compared to
endothelial NOS (eNOS) and inducible NOS (iNOS) may be useful to treat cerebral ischemia
(stroke) and other neurodegenerative diseases. S-Methyl-L-thiocitrulline (Me-TC) and S-
ethyl-L-thiocitrulline (Et-TC) inhibited the oxidation of L-arginine and the L-arginine-
independent oxidation of NADPH by nNOS from human brain. Me-TC and Et-TC were slow,
tight binding inhibitors of nNOS with second-order association rate constants (kon) of 2.6 x …
endothelial NOS (eNOS) and inducible NOS (iNOS) may be useful to treat cerebral ischemia
(stroke) and other neurodegenerative diseases. S-Methyl-L-thiocitrulline (Me-TC) and S-
ethyl-L-thiocitrulline (Et-TC) inhibited the oxidation of L-arginine and the L-arginine-
independent oxidation of NADPH by nNOS from human brain. Me-TC and Et-TC were slow,
tight binding inhibitors of nNOS with second-order association rate constants (kon) of 2.6 x …
