[HTML][HTML] MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome
T Nikitina, RP Ghosh, RA Horowitz-Scherer… - Journal of Biological …, 2007 - ASBMB
hMeCP2 (human methylated DNA-binding protein 2), mutations of which cause most cases
of Rett syndrome (RTT), is involved in the transmission of repressive epigenetic signals
encoded by DNA methylation. The present work focuses on the modifications of chromatin
architecture induced by MeCP2 and the effects of RTT-causing mutants. hMeCP2 binds to
nucleosomes close to the linker DNA entry-exit site and protects∼ 11 bp of linker DNA from
micrococcal nuclease. MeCP2 mutants differ in this property; the R106W mutant gives very …
of Rett syndrome (RTT), is involved in the transmission of repressive epigenetic signals
encoded by DNA methylation. The present work focuses on the modifications of chromatin
architecture induced by MeCP2 and the effects of RTT-causing mutants. hMeCP2 binds to
nucleosomes close to the linker DNA entry-exit site and protects∼ 11 bp of linker DNA from
micrococcal nuclease. MeCP2 mutants differ in this property; the R106W mutant gives very …
