Factor XII–independent cleavage of high-molecular-weight kininogen by prekallikrein and inhibition by C1 inhibitor
K Joseph, BG Tholanikunnel, AP Kaplan - Journal of allergy and clinical …, 2009 - Elsevier
BACKGROUND: Bradykinin formation typically requires interaction of Factor XII, prekallikrein
(PK), and high-molecular-weight kininogen (HK) with negatively charged exogenous
initiators or cell-surface proteins. Approximately 85% of plasma PK circulates as a complex
with HK. Nonenzymatic cell-derived initiators, such as heat shock protein 90, can activate
the HK-PK complex to generate kallikrein, bradykinin, and cleaved HK, even in the absence
of Factor XII. OBJECTIVE: We sought to determine whether PK, without activation to …
(PK), and high-molecular-weight kininogen (HK) with negatively charged exogenous
initiators or cell-surface proteins. Approximately 85% of plasma PK circulates as a complex
with HK. Nonenzymatic cell-derived initiators, such as heat shock protein 90, can activate
the HK-PK complex to generate kallikrein, bradykinin, and cleaved HK, even in the absence
of Factor XII. OBJECTIVE: We sought to determine whether PK, without activation to …