A novel NF-κB pathway involving IKKβ and p65/RelA Ser-536 phosphorylation results in p53 inhibition in the absence of NF-κB transcriptional activity
SJ Jeong, CA Pise-Masison, MF Radonovich… - Journal of Biological …, 2005 - ASBMB
Nuclear factor κB (NF-κB) plays an important role in regulating cellular transformation and
apoptosis. The human T-cell lymphotropic virus type I protein, Tax, which is critical for viral
transformation, modulates the transcription of several cellular genes through activation of NF-
κB. We have demonstrated previously that Tax inhibits p53 activity through the p65/RelA
subunit of NF-κB. We now present evidence that suggests that the upstream kinase IKKβ
plays an important role in Tax-induced p53 inhibition through phosphorylation of p65/RelA …
apoptosis. The human T-cell lymphotropic virus type I protein, Tax, which is critical for viral
transformation, modulates the transcription of several cellular genes through activation of NF-
κB. We have demonstrated previously that Tax inhibits p53 activity through the p65/RelA
subunit of NF-κB. We now present evidence that suggests that the upstream kinase IKKβ
plays an important role in Tax-induced p53 inhibition through phosphorylation of p65/RelA …
