Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses
JC Krause, TM Tumpey, CJ Huffman… - Journal of …, 2010 - Am Soc Microbiol
Journal of virology, 2010•Am Soc Microbiol
The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence
homology with the 1918 pandemic influenza virus. We found that human monoclonal
antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009
hemagglutinins, a site that is hypervariable due to immune selection. These antibodies
exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic
effect in vivo.
homology with the 1918 pandemic influenza virus. We found that human monoclonal
antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009
hemagglutinins, a site that is hypervariable due to immune selection. These antibodies
exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic
effect in vivo.
Abstract
The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro, and one exerted a marked therapeutic effect in vivo.
American Society for Microbiology