Liver carcinogenesis by diethylnitrosamine in the rat
MF Rajewsky, W Dauber, H Frankenberg - Science, 1966 - science.org
MF Rajewsky, W Dauber, H Frankenberg
Science, 1966•science.orgDiethylnitrosamine was continuously administered to rats at a dose rate of low toxicity.
Ninety-two percent of the animals died with multicentrical hepatocellular carcinomata within
a narrow and highly reproducible time interval. Discontinuing the carcinogen during the
experiment resulted in a prolonged median time until death, a reduced tumor yield, and a
lessened slope of the dose-response curve. Partial hepatectomy after discontinuation of the
drug did not change either tumor yield or time of death. The obtained dose-response …
Ninety-two percent of the animals died with multicentrical hepatocellular carcinomata within
a narrow and highly reproducible time interval. Discontinuing the carcinogen during the
experiment resulted in a prolonged median time until death, a reduced tumor yield, and a
lessened slope of the dose-response curve. Partial hepatectomy after discontinuation of the
drug did not change either tumor yield or time of death. The obtained dose-response …
Diethylnitrosamine was continuously administered to rats at a dose rate of low toxicity. Ninety-two percent of the animals died with multicentrical hepatocellular carcinomata within a narrow and highly reproducible time interval. Discontinuing the carcinogen during the experiment resulted in a prolonged median time until death, a reduced tumor yield, and a lessened slope of the dose-response curve. Partial hepatectomy after discontinuation of the drug did not change either tumor yield or time of death. The obtained dose-response relationships support the concept that carcinogenic effects of single doses are irreversible and cumulative. Daily, low-dose, total-body x-irradiation had no significant effect on the response of rat liver to the carcinogen.
![](/scholar/images/qa_favicons/sciencemag.org.png)