Obesity is associated with metabolic derangements in multiple tissues, which contribute to
the progression of insulin resistance and the metabolic syndrome. The underlying stimulus
for these metabolic derangements in obesity are not fully elucidated, however recent
evidence in rodents and humans suggests that systemic, low level elevations of gut derived
endotoxin (lipopolysaccharide, LPS) may play an important role in obesity related, whole-
body and tissue specific metabolic perturbations. LPS initiates a well-characterized …