Maternal obesity associated with inflammation in their children
KL Leibowitz, RH Moore, RS Ahima… - World Journal of …, 2012 - Springer
KL Leibowitz, RH Moore, RS Ahima, AJ Stunkard, VA Stallings, RI Berkowitz, JL Chittams…
World Journal of Pediatrics, 2012•SpringerBackground This study explored the association between maternal obesity during
pregnancy and the inflammatory markers, tumor necrosis factor-α, interleukin-6 and high
sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring.
Methods Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-
old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk
(LR) groups based on maternal pre-pregnancy body mass index (BMI). Results The two …
pregnancy and the inflammatory markers, tumor necrosis factor-α, interleukin-6 and high
sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring.
Methods Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-
old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk
(LR) groups based on maternal pre-pregnancy body mass index (BMI). Results The two …
Background
This study explored the association between maternal obesity during pregnancy and the inflammatory markers, tumor necrosis factor-α, interleukin-6 and high sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring.
Methods
Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk (LR) groups based on maternal pre-pregnancy body mass index (BMI).
Results
The two groups differed markedly in their hs-CRP levels, but no group difference was found for the other three biomarkers. The odds ratio (OR) of HR children having detectable hs-CRP levels was 16 times greater than that of LR children after adjusting for confounding variables, including BMI z-score, Tanner stages and gender (OR: 16; 95% CI: 2–123).
Conclusions
These results suggest that maternal obesity during pregnancy is associated with later development of elevated hs-CRP in the offspring, even after controlling for weight.
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