The formation of new vessels in the tumor, termed angiogenesis, is essential for primary
tumor growth and facilitates tumor invasion and metastasis. Hypoxia has been described as
one trigger of angiogenesis. Indeed, hypoxia, which is characterized by areas of low oxygen
levels, is a hallmark of solid tumors arising from an imbalance between oxygen delivery and
consumption. Hypoxic conditions have profound effects on the different components of the
tumoral environment. For example, hypoxia is able to activate endothelial cells, leading to …