[HTML][HTML] Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway
MS Buzza, EW Martin, KH Driesbaugh… - Journal of Biological …, 2013 - ASBMB
The type II transmembrane serine protease matriptase is a key regulator of epithelial barriers
in skin and intestine. In skin, matriptase acts upstream of the glycosylphosphatidylinositol-
anchored serine protease, prostasin, to activate the prostasin zymogen and initiate a
proteolytic cascade that is required for stratum corneum barrier functionality. Here, we have
investigated the relationship between prostasin and matriptase in intestinal epithelial barrier
function. We find that similar to skin, matriptase and prostasin are components of a common …
in skin and intestine. In skin, matriptase acts upstream of the glycosylphosphatidylinositol-
anchored serine protease, prostasin, to activate the prostasin zymogen and initiate a
proteolytic cascade that is required for stratum corneum barrier functionality. Here, we have
investigated the relationship between prostasin and matriptase in intestinal epithelial barrier
function. We find that similar to skin, matriptase and prostasin are components of a common …