Decreased expression of the glucocorticoid receptor-GILZ pathway in Kupffer cells promotes liver inflammation in obese mice
O Robert, H Boujedidi, A Bigorgne, G Ferrere… - Journal of …, 2016 - Elsevier
Background & Aims Kupffer cells (KC) play a key role in the onset of inflammation in non-
alcoholic steatohepatitis (NASH). The glucocorticoid receptor (GR) induces glucocorticoid-
induced leucine zipper (GILZ) expression in monocytes/macrophages and is involved in
several inflammatory processes. We hypothesized that the GR-GILZ axis in KC may
contribute to the pathophysiology of obesity-induced liver inflammation. Methods By using a
combination of primary cell culture, pharmacological experiments, mice deficient for the Gr …
alcoholic steatohepatitis (NASH). The glucocorticoid receptor (GR) induces glucocorticoid-
induced leucine zipper (GILZ) expression in monocytes/macrophages and is involved in
several inflammatory processes. We hypothesized that the GR-GILZ axis in KC may
contribute to the pathophysiology of obesity-induced liver inflammation. Methods By using a
combination of primary cell culture, pharmacological experiments, mice deficient for the Gr …