Interleukin-1 receptor antagonist suppresses experimental autoimmune encephalomyelitis (EAE) in rats by influencing the activation and proliferation of …

V Badovinac, M Mostarica-Stojković… - Journal of …, 1998 - Elsevier
Considering the role of pleiotropic interleukin-1 (IL-1) in inflammation and autoimmunity,
studies were designed to examine whether specific blockade of IL-1 may influence these
processes in the CNS. Although the role of CD4+ T cells in eliciting clinical signs of
experimental autoimmune encephalomyelitis (EAE) has been unequivocally demonstrated,
the exact mechanism by which encephalitogenic cells initiate disease process and bring
about clinical signs still remains to be defined. We have evaluated the effect of human …