[HTML][HTML] The clinical use of PET with 11C-acetate

I Grassi, C Nanni, V Allegri, JJ Morigi… - American journal of …, 2012 - ncbi.nlm.nih.gov
I Grassi, C Nanni, V Allegri, JJ Morigi, GC Montini, P Castellucci, S Fanti
American journal of nuclear medicine and molecular imaging, 2012ncbi.nlm.nih.gov
The aim of this review is to evaluate clinical applications of 11 C-acetate positron emission
tomography (PET). Acetate is quickly metabolized into acetyl-CoA in human cells. In this
form it can either enter into the tricarboxylic acid cycle, thus producing energy, as happens in
the myocardium, or participate in cell membrane lipid synthesis, as happens in tumor cells.
11 C-acetate PET was originally employed in cardiology, to study myocardial oxygen
metabolism. More recently it has also been used to evaluate myocardial perfusion, as well …
Abstract
The aim of this review is to evaluate clinical applications of 11 C-acetate positron emission tomography (PET). Acetate is quickly metabolized into acetyl-CoA in human cells. In this form it can either enter into the tricarboxylic acid cycle, thus producing energy, as happens in the myocardium, or participate in cell membrane lipid synthesis, as happens in tumor cells. 11 C-acetate PET was originally employed in cardiology, to study myocardial oxygen metabolism. More recently it has also been used to evaluate myocardial perfusion, as well as in oncology. The first studies of 11 C-acetate focused on its use in prostate cancer. Subsequently, 11 C-acetate was studied in other urological malignancies, as well as renal cell carcinoma and bladder cancer. Well differentiated hepatocellular carcinoma represents an 18 F-fluoro-deoxyglucose (18 F-FDG) PET pitfall, so many authors have proposed to use 11 C-acetate in addition to 18 F-FDG in studying this tumor. 11 C-acetate PET has also been used in other malignancies, such as brain tumors and lung carcinoma. Some authors reported a few cases in which 11 C-acetate PET incidentally found multiple myeloma or rare tumors, such as thymoma, multicentric angiomyolipoma of the kidney and cerebellopontine angle schwannoma. Lastly, 11 C-acetate PET was also employed in a differential diagnosis case between glioma and encephalitis. The numerous studies on 11 C-acetate have demonstrated that it can be used in cardiology and oncology with no contraindications apart from pregnancy and the necessity of a rapid scan. Despite its limited availability, this tracer can surely be considered to be a promising one, because of its versatility and capacity to even detect non 18 F-FDG-avid neoplasm, such as differentiated lung cancer or hepatocellular carcinoma.
ncbi.nlm.nih.gov