Perineural invasion by ductal adenocarcinoma of the pancreas
T Takahashi, H Ishikura, T Motohara… - Journal of surgical …, 1997 - Wiley Online Library
T Takahashi, H Ishikura, T Motohara, SI Okushiba, M Dohke, H Katoh
Journal of surgical oncology, 1997•Wiley Online LibraryAbstract Background and Objectives The correlation between various levels of perineural
invasion by pancreatic carcinoma and the patient's prognosis has never been cleared. The
authors carried out a histopathologic study of resected pancreatic carcinoma to elucidate the
significance of a new histologic finding concerning perineural invasion, which we
designated “ntrapancreatic, extratumoral perineural invasion (nex),” and also to determine
its predictive value for prognoses of patients after surgical removal of the tumor. Methods We …
invasion by pancreatic carcinoma and the patient's prognosis has never been cleared. The
authors carried out a histopathologic study of resected pancreatic carcinoma to elucidate the
significance of a new histologic finding concerning perineural invasion, which we
designated “ntrapancreatic, extratumoral perineural invasion (nex),” and also to determine
its predictive value for prognoses of patients after surgical removal of the tumor. Methods We …
Background and Objectives
The correlation between various levels of perineural invasion by pancreatic carcinoma and the patient's prognosis has never been cleared. The authors carried out a histopathologic study of resected pancreatic carcinoma to elucidate the significance of a new histologic finding concerning perineural invasion, which we designated “ntrapancreatic, extratumoral perineural invasion (nex),” and also to determine its predictive value for prognoses of patients after surgical removal of the tumor.
Methods
We investigated 90 patients with pancreatic adenocarcinoma who had undergone pancreatic resection. The prognoses of all patients were explored, and correlations between survival and pathologic factors were statistically examined for neural invasion.
Results
Nex was found in more than 50% of resected pancreases. A statistically significant association was found between the presence of nex and the grade of intrapancreatic neural invasion or the presence of extrapancreatic neural plexus invasion. Nex was also found to be associated with patient survival after removal of the tumor.
Conclusions
Nex appears to be an element predicting pancreatic cancer infiltration to the extrapancreatic nerve plexus and also to be a factor influencing postoperative survival of patients with pancreatic carcinoma. J. Surg. Oncol. 1997;65:164–170. © 1997 Wiley‐Liss, Inc.
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