Increased thirst and drinking in Huntington's disease and the R6/2 mouse
NI Wood, AOG Goodman, JMM van der Burg… - Brain Research …, 2008 - Elsevier
While Huntington's disease (HD) is a condition that primarily involves the basal ganglia,
there is evidence to suggest that the hypothalamus is also affected. Because the
osmoreceptors regulating thirst are situated in the circumventricular region of the
hypothalamus, we were interested in whether altered thirst is a part of the HD phenotype.
We used the LABORAS behavioural monitoring system and water consumption to show that
drinking behaviour was abnormal in R6/2 mice. By 10 weeks of age, R6/2 mice spent …
there is evidence to suggest that the hypothalamus is also affected. Because the
osmoreceptors regulating thirst are situated in the circumventricular region of the
hypothalamus, we were interested in whether altered thirst is a part of the HD phenotype.
We used the LABORAS behavioural monitoring system and water consumption to show that
drinking behaviour was abnormal in R6/2 mice. By 10 weeks of age, R6/2 mice spent …
