The orphan nuclear receptor Rev-Erbα is a peroxisome proliferator-activated receptor (PPAR) γ target gene and promotes PPARγ-induced adipocyte differentiation
C Fontaine, G Dubois, Y Duguay, T Helledie… - Journal of Biological …, 2003 - ASBMB
Rev-Erbα (NR1D1) is an orphan nuclear receptor encoded on the opposite strand of the
thyroid receptor α gene. Rev-Erbα mRNA is induced during adipocyte differentiation of 3T3-
L1 cells, and its expression is abundant in rat adipose tissue. Peroxisome proliferator-
activated receptor γ (PPARγ)(NR1C3) is a nuclear receptor controlling adipocyte
differentiation and insulin sensitivity. Here we show that Rev-Erbα expression is induced by
PPARγ activation with rosiglitazone in rat epididymal and perirenal adipose tissues in vivo …
thyroid receptor α gene. Rev-Erbα mRNA is induced during adipocyte differentiation of 3T3-
L1 cells, and its expression is abundant in rat adipose tissue. Peroxisome proliferator-
activated receptor γ (PPARγ)(NR1C3) is a nuclear receptor controlling adipocyte
differentiation and insulin sensitivity. Here we show that Rev-Erbα expression is induced by
PPARγ activation with rosiglitazone in rat epididymal and perirenal adipose tissues in vivo …
