Enteroendocrine cell signalling via the vagus nerve
GJ Dockray - Current opinion in pharmacology, 2013 - Elsevier
Highlights•Vagal afferents to the gut are activated by CCK, leptin, 5HT, GLP-1 and PYY 3–
36.•The actions of CCK on vagal afferents are potentiated by leptin.•In diet induced obesity
there is vagal afferent insensitivity to leptin and CCK.•The neurochemical phenotype of
vagal afferents changes in obesity and with fasting.•fMRI reveals interactions between CCK
and ghrelin in gut-brain signalling in humans.Nutrient delivery to the gut activates
neuroendocrine mechanisms that control digestion and energy intake and utilisation. These …
36.•The actions of CCK on vagal afferents are potentiated by leptin.•In diet induced obesity
there is vagal afferent insensitivity to leptin and CCK.•The neurochemical phenotype of
vagal afferents changes in obesity and with fasting.•fMRI reveals interactions between CCK
and ghrelin in gut-brain signalling in humans.Nutrient delivery to the gut activates
neuroendocrine mechanisms that control digestion and energy intake and utilisation. These …
