[HTML][HTML] mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action
GA Soliman, HA Acosta-Jaquez, EA Dunlop… - Journal of Biological …, 2010 - ASBMB
The mammalian target of rapamycin (mTOR) Ser/Thr kinase signals in at least two
multiprotein complexes distinguished by their different partners and sensitivities to
rapamycin. Acute rapamycin inhibits signaling by mTOR complex 1 (mTORC1) but not
mTOR complex 2 (mTORC2), which both promote cell growth, proliferation, and survival.
Although mTORC2 regulation remains poorly defined, diverse cellular mitogens activate
mTORC1 signaling in a manner that requires sufficient levels of amino acids and cellular …
multiprotein complexes distinguished by their different partners and sensitivities to
rapamycin. Acute rapamycin inhibits signaling by mTOR complex 1 (mTORC1) but not
mTOR complex 2 (mTORC2), which both promote cell growth, proliferation, and survival.
Although mTORC2 regulation remains poorly defined, diverse cellular mitogens activate
mTORC1 signaling in a manner that requires sufficient levels of amino acids and cellular …