[HTML][HTML] RNA editing of androgen receptor gene transcripts in prostate cancer cells
HD Martinez, RJ Jasavala, I Hinkson… - Journal of biological …, 2008 - ASBMB
Reactivation of the androgen receptor (AR) signaling pathway represents a critical step in
the growth and survival of androgen-independent (AI) prostate cancer (CaP). In this study
we show the DU145 and PC3 AI human CaP cell lines respond to androgens and require
AR expression for optimal proliferation in vitro. Interestingly, AR gene transcripts in DU145
and PC3 cells harbored a large number of single base pair nucleotide transitions that
resulted in missense mutations in selected AR codons. The most notable lesion detected in …
the growth and survival of androgen-independent (AI) prostate cancer (CaP). In this study
we show the DU145 and PC3 AI human CaP cell lines respond to androgens and require
AR expression for optimal proliferation in vitro. Interestingly, AR gene transcripts in DU145
and PC3 cells harbored a large number of single base pair nucleotide transitions that
resulted in missense mutations in selected AR codons. The most notable lesion detected in …