Identifying RNA editing sites using RNA sequencing data alone
Nature methods, 2013•nature.com
We show that RNA editing sites can be called with high confidence using RNA sequencing
data from multiple samples across either individuals or species, without the need for
matched genomic DNA sequence. We identified many previously unidentified editing sites in
both humans and Drosophila; our results nearly double the known number of human protein
recoding events. We also found that human genes harboring conserved editing sites within
Alu repeats are enriched for neuronal functions.
data from multiple samples across either individuals or species, without the need for
matched genomic DNA sequence. We identified many previously unidentified editing sites in
both humans and Drosophila; our results nearly double the known number of human protein
recoding events. We also found that human genes harboring conserved editing sites within
Alu repeats are enriched for neuronal functions.
Abstract
We show that RNA editing sites can be called with high confidence using RNA sequencing data from multiple samples across either individuals or species, without the need for matched genomic DNA sequence. We identified many previously unidentified editing sites in both humans and Drosophila; our results nearly double the known number of human protein recoding events. We also found that human genes harboring conserved editing sites within Alu repeats are enriched for neuronal functions.
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