Autoinflammatory diseases (AIDs) are illnesses caused by primary dysfunction of the innate
immune system. Proteins that are mutated in AIDs mediate the regulation of NFκB activation,
cell apoptosis, and IL-1β secretion through cross-regulated and sometimes common
signaling pathways. AIDs include a broad number of monogenic [eg, familial Mediterranean
fever (FMF), cryopyrin-associated periodic syndrome (CAPS), mevalonate kinase deficiency
(MKD), tumor necrosis factor (TNF)-receptor-associated periodic syndrome (TRAPS)] and …