Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms
A Jamshidian, V Shaygannejad, A Pourazar… - Journal of …, 2013 - Elsevier
The opposing immune functions of Treg and Th17 lymphocytes and the plasticity of
Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and
counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and
Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease
in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these
subsets was observed in controls but not in patient groups. Both Treg frequency and …
Treg/Th17 differentiation, has led us to investigate the effects of their fluctuations and
counterbalance in autoimmune condition of multiple sclerosis (MS). Evaluation of Treg and
Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease
in Treg/Th17 ratio compared to that of healthy controls. A reverse correlation between these
subsets was observed in controls but not in patient groups. Both Treg frequency and …
