Erasers of histone acetylation: the histone deacetylase enzymes

E Seto, M Yoshida - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
E Seto, M Yoshida
Cold Spring Harbor perspectives in biology, 2014cshperspectives.cshlp.org
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional
groups from the lysine residues of both histone and nonhistone proteins. In humans, there
are 18 HDAC enzymes that use either zinc-or NAD+-dependent mechanisms to deacetylate
acetyl lysine substrates. Although removal of histone acetyl epigenetic modification by
HDACs regulates chromatin structure and transcription, deacetylation of nonhistones
controls diverse cellular processes. HDAC inhibitors are already known potential anticancer …
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. In humans, there are 18 HDAC enzymes that use either zinc- or NAD+-dependent mechanisms to deacetylate acetyl lysine substrates. Although removal of histone acetyl epigenetic modification by HDACs regulates chromatin structure and transcription, deacetylation of nonhistones controls diverse cellular processes. HDAC inhibitors are already known potential anticancer agents and show promise for the treatment of many diseases.
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