[HTML][HTML] Sheets of human retinal progenitor transplants improve vision in rats with severe retinal degeneration
B Lin, BT McLelland, A Mathur, RB Aramant… - Experimental eye …, 2018 - Elsevier
Loss of photoreceptors and other retinal cells is a common endpoint in retinal degenerate
(RD) diseases that cause blindness. Retinal transplantation is a potential therapy to replace
damaged retinal cells and improve vision. In this study, we examined the development of
human fetal retinal sheets with or without their retinal pigment epithelium (RPE) transplanted
to immunodeficient retinal degenerate rho S334ter-3 rats. Sheets were dissected from fetal
human eyes (11–15.7 weeks gestation) and then transplanted to the subretinal space of 24 …
(RD) diseases that cause blindness. Retinal transplantation is a potential therapy to replace
damaged retinal cells and improve vision. In this study, we examined the development of
human fetal retinal sheets with or without their retinal pigment epithelium (RPE) transplanted
to immunodeficient retinal degenerate rho S334ter-3 rats. Sheets were dissected from fetal
human eyes (11–15.7 weeks gestation) and then transplanted to the subretinal space of 24 …