ATP autocrine/paracrine signaling induces calcium oscillations and NFAT activation in human mesenchymal stem cells
S Kawano, K Otsu, A Kuruma, S Shoji, E Yanagida… - Cell calcium, 2006 - Elsevier
Human bone marrow-derived mesenchymal stem cells (hMSCs) have the potential to
differentiate into several types of cells. Calcium ions (Ca2+) play an important role in the
differentiation and proliferation of hMSCs. We have demonstrated that spontaneous [Ca2+] i
oscillations occur without agonist stimulation in hMSCs. However, the precise mechanism of
its generation remains unclear. In this study, we investigated the mechanism and role of
spontaneous [Ca2+] i oscillations in hMSCs and found that IP3-induced Ca2+ release is …
differentiate into several types of cells. Calcium ions (Ca2+) play an important role in the
differentiation and proliferation of hMSCs. We have demonstrated that spontaneous [Ca2+] i
oscillations occur without agonist stimulation in hMSCs. However, the precise mechanism of
its generation remains unclear. In this study, we investigated the mechanism and role of
spontaneous [Ca2+] i oscillations in hMSCs and found that IP3-induced Ca2+ release is …